As of my last update in September 2021, React does not directly support reconciling DOM nodes based on globally-unique identifiers (GUIDs) out of the box. The React reconciliation process relies on the Virtual DOM diffing algorithm, which efficiently updates the actual DOM based on changes to the component tree's state and props.

React's reconciliation process works by comparing elements' keys (if provided) and their structure in the component tree. When elements are added, removed, or rearranged in the component tree, React efficiently updates the corresponding DOM nodes.

While React doesn't directly support reconciling by GUIDs, you can achieve a similar effect by using keys on the elements you render. By providing keys to your components, React can use those keys during the reconciliation process to efficiently update the DOM.

Here's an example of how to use keys with components:

function MyComponent({ items }) { return ( <ul> { => ( <li key={}>{item.text}</li> ))} </ul> ); }

In this example, each item in the items array has a unique id property. By using key={} in the list, React will be able to efficiently update the DOM when items are added, removed, or rearranged in the items array.

Keep in mind that keys should be unique among siblings, but not necessarily globally unique. In practice, using unique identifiers within a specific context is often sufficient for efficient reconciliation.

If you have a specific use case where globally-unique identifiers are necessary for reconciliation, you might need to implement custom logic or extensions to React to achieve the desired behavior. However, it's important to carefully evaluate whether this is necessary, as React's default reconciliation approach is highly optimized for most use cases.

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